Skinesse

Skinesse is the most effective and innovative sterile meso-cocktails for hyperpigmentations, melasma, sun damage, age spots, dyschromias, acne scars. Skinesse contains a complete formula thanks to its active ingredients that work in synergy.

Skinesse’s action is fast and visible from the first session.
Skinesse contains natural ingredients, based on Kudzu root nodules (symbiozomes).
Similar structure to Hemoglobin in humans: acts as detoxyfier of free radicals skin lightener active. Adjusts the activity of tyrosinase.
and helps to control melanogenesis through scavenging of nitrogen oxide (NO) radicals.

Additional activities:
It also improves skin elasticity, stimulates production of collagen Curative action in Hyperpigmentation and tanned skins.
It also contains Isoflavones Pueraria, antioxidant properties.It is not cytotoxic and is very stable in water solutions.

How it works?

Step 1: Reduces NO• (melanogenic mediator) production

Step 2: Inhibits Tyrosinase and other enzymes as TRP-1

Step 3: Controls Melanosome transfer

Additional activities:
Antioxidant, protection against UVA/ UVB, inflammation inhibitor, improves cell metabolism, protection of dermal matrix fibres.
Reduces the melanin quantity and also inhibits melanocytes dendricity, making difficult the melanosome trasfer to keratinocytes, in just 10 days.

Albatin
It is a Phosphinic analogue of Alanine (Ala-P).

It is not cytotoxic and very stable in water solutions How it works?
Albatin stabilizes DOPAchrome and inhibits the enzymatic activity of the
DOPAchrome tautomerase (TRP-2).

Glutathione
Mechanism of action: it reduces the intermediates of the melanin. Glutation has a reducing group
(SH) which can form a complex with copper and also reduces dopaquinone to DOPA.

Alpha Arbutin
Arbutin is a glycoside; a glycosylated hydroquinone extracted.
Human melanocytes exposed to arbutin at concentrations below 300 μg/mL reported decreased tyrosinase activity and melanin content with little evidence of cytotoxicity.